Client trace will reveal the following (for Enterprise Vault Search):
Launching EV web application in Outlook: https://EV/EnterpriseVault/search/shell.aspx?server=EXMB1&mbx=SMTP:user1@evrpslab.com&vaultid=17872B31D86F58D4B9BAB62585DA24C121110000EV&NAV=0
Snippet from IIS Log on the Enterprise Vault Server:
192.168.2.115 GET /EnterpriseVault/search/shell.aspx server=EXMB1&mbx=SMTP:user1@evrpslab.com&vaultid=17872B31D86F58D4B9BAB62585DA24C121110000EV&NAV=0 443 - 192.168.2.141 Mozilla/5.0+(Windows+NT+10.0;+Win64;+x64)+AppleWebKit/537.36+(KHTML,+like+Gecko)+Chrome/64.0.3282.140+Safari/537.36+Edge/17.17134 - 404 19 0 0
This issue can be caused if request filtering is enabled in the IIS on the 'Search' virtual directory.
Edit the rule configured in 'Request Filtering' under the 'Search' virtual directory and remove '.aspx' from the Applies To field.
Note: An IIS restart might be needed for this change to take effect.